Cry1Ab | BCH-GENE-SCBD-14985 | Genetic element | Biosafety Clearing-House


Genetic element (GENE)

published: 12 Jun 2006 last updated: 27 Feb 2014
General information
Protein coding sequence
Donor organism
Characteristics of the protein coding sequence
Cry1Ab delta-endotoxin
The cry1Ab gene codes for a delta-endotoxin, commonly known as "Bt-toxin", which confers resistance to the plant to lepidoptera larvae such as the European corn borer (Ostrinia nubilalis), the southwestern corn borer (Diatraea grandiosella), pink borer (Sesamia cretica), Spruce Budworm, Tent caterpillar, Gypsy moth, Diamondback moth, Cabbage looper, Tobacco budworm, and Cabbage worm.
Additional Information
Cry proteins, of which Cry1Ab is only one, act by selectively binding to specific sites localized on the lining of the midgut of susceptible insect species. Following binding, pores are formed that disrupt midgut ion flow, causing gut paralysis and eventual death due to bacterial sepsis. Cry1Ab is lethal only when eaten by the larvae of lepidopteran insects (moths and butterflies), and its specificity of action is directly attributable to the presence of specific binding sites in the target insects.
Records referencing this document Show in search
Record type Field Record(s)
Living Modified Organism Introduced or modified genetic element(s) 106
Living Modified Organism Genetic elements construct 104
Laboratory for detection and identification of LMOs Genetic element(s) detectable by the laboratory 13