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Genetic element (GENE)
last updated: 14 Jan 2022
Protein coding sequence
The synthetic Cry1Da_7 protein is a chimeric protein consisting of the Cry1Da1 core toxin domain with three aa substitutions in the active core (S282V, Y316S, I368P) and the Cry1Ab3 protoxin domain. The protein binds different receptors compared to other commonly available Bt proteins, such as Cry1F, Cry1A.105, Cry2Ab and Vip3A, but continues to demonstrate a pore-forming mode of action. Thus, the protein causes mortality and developmental delay in susceptible Lepidoptera insects, such as fall armyworm and corn earworms. In assays using Cry1F-resistant fall armyworm colonies, the protein overcame the insect's Bt-resistance.