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Genetic element
(GENE)
last updated: 23 Mar 2023
Alpha-amylase inhibitor-1
EN
-
αAI-1EN
-
LLPEN
CS-llp-PHAVU
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-104363-6 Organism Phaseolus vulgaris (String bean, French bean, Kidney bean, Common Bean , PHAVU)Crops
Phaseolus vulgaris cv. Tendergreen
Alpha-amylase inhibitor 1
EN
Alpha-amylase inhibitor 1 acts as a defensive protein against insects by binding and inhibiting alpha-amylase. The protein consists of a heterotetramer of two α chains and two β chains. Proteolytic processing of the proprotein is required to produce the active molecule, which then blocks the catalytic site of the enzyme (tyrosine-186 and tyrosine-37 interact with the catalytic site). Inhibition of alpha-amylase proteins interferes with carbohydrate digestion, negatively impacting the growth, fecundity, and survival of the insect pest.
EN
May cause an allergic reaction in humans.
- UniProtKB - Alpha-amylase inhibitor 1 [ English ]
- [Phytochemistry] Inhibitory specificity and insecticidal selectivity of α-amylase inhibitor from Phaseolus vulgaris [ English ]
- [Plant Physiology] Activation of Bean (Phaseolus vulgaris) α--Amylase Inhibitor Requires Proteolytic Processing of the Proprotein [ English ]
- [Biochimica et Biophysica Acta - General Subjects] Molecular determinant for specificity: Differential interaction of α-amylases with their proteinaceous inhibitors [ English ]
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