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Genetic element (GENE)
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last updated: 20 Feb 2025
General information
2A-like self-processing peptide
EN
  • 2A-like self-cleaving peptide
    EN
O-2A-THAV
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Other (Spacer)
No
Donor organism
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Additional Information
The Thosea asigna virus 2A-like self-processing peptide is commonly used in genetic engineering to achieve polycistronic expression (expression of multiple proteins from a single mRNA transcript) at defined stoichiometries. The peptide is associated with the capsid precursor protein. Upon translation, ribosome skipping occurs and thus peptide bonds fail to form. When used as a spacer between protein coding sequences, individual proteins can then be separated from each other following translation. This peptide sequence has been used in different eukaryotic systems (animals, plants). Several viral species that infect a broad range of eukaryotic hosts also encode peptide sequences with similar functionalities (2A peptide system).
EN
Records referencing this document Show in search
Record type Field Record(s)
Living Modified Organism Introduced or modified genetic element(s) 1
Living Modified Organism Genetic elements construct 1