The Resistance gene is a member of the NBS-LRR (Nucleotide Binding Site - Leucine Rich Repeat) class and codes for a protein that recognizes specific proteins of Phytophthora infestans termed elicitor proteins which are the causing agent of late-blight disease. Rpi-blb2 is a coiled-coil nucleotide-binding leucine-rich repeat (CC-NC-NLR) resistance protein with 1267 aa from Solanum americanum. Upon binding this effector, Rpi-blb2 undergoes ATP-dependent conformational change via its functional domain, Nucleotide-binding and Apaf-1, R-protein, and CED-4 (NB-ARC). Recognition of the elicitor proteins will lead to local plant cell death and will thus prevent further development of the pathogen Phytophthora infestans.