5-enolpyruvylshikimate-3-phosphate synthase | Escherichia coli (ECOLX) | BCH-GENE-SCBD-45913 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)

last updated: 12 Feb 2021
General information
5-enolpyruvylshikimate-3-phosphate synthase
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  • aroA
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CS-aroa-ECOLX
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Protein coding sequence
No
Donor organism
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Characteristics of the protein coding sequence
5-enolpyruvylshikimate-3-phosphate synthase
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Involved in EPSP biosynthesis. The aroA gene, which encodes 5-enolpyruvylshikimate-3-phosphate synthase , an enzyme of the common aromatic biosynthetic pathway, the enzyme participates in biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan.

The enzyme is a target for herbicides as these amino acids are only synthesized in plants and microorganisms. Glyphosate acts as a competitive inhibitor for phosphoenolpyruvate, as substrate of EPSPS, and is used as a broad-spectrum systemic herbicide.
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Additional Information
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