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Genetic element (GENE)
published: 05 Mar 2009
last updated: 18 Feb 2021
Glyphosate-N-Acteyltransferase gene
EN
CS-gat-BACLI
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-48360-3 Organism Bacillus licheniformis (BACLI)Bacteria
EN
Glyphosate-N-Acteyltransferase
EN
Glyphosate-N-acetyltransferase expression in genetically modified plants may lead to detoxification of the glyphosate agent. This is brought about by the transfer of an acetyl group from acetyl CoA to the secondary amine group of glyphosate.
The resulting N-acetylglyphosate does not have the ability to inhibit the activity of the EPSPS enzyme, and the genetically modified plants are able to grow despite glyphosate treatment.
EN
The resulting N-acetylglyphosate does not have the ability to inhibit the activity of the EPSPS enzyme, and the genetically modified plants are able to grow despite glyphosate treatment.
Two modified versions of the GAT gene were developed using a DNA shuffling technique using the GAT coding sequences from 3 separate strains of B. licheniformis (Strains B6, 401 and DS3).
The two versions are known as GAT4621 and GAT4601.
EN
The two versions are known as GAT4621 and GAT4601.
- Evolution of a microbial acetyltransferase for modification of glyphosate: a novel tolerance strategy [ English ]
- GAT4621 - Food and Drug Administration.pdf [ English ]
- GAT4601 - Food and Drug Administration.pdf [ English ]
- Discovery and Directed Evolution of a Glyphosate Tolerance Gene.pdf [ English ]
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