These Guidelines have been adapted from this Guidance Framework for testing of GM mosquito by WHO with some sections reproduced verbatim. The guidelines are aimed to support regulators in the identification of potential risks that might be caused during the development and testing of GM mosquitoes and guide applicants in planning and conducting safety assessments in support of their activities involving GM mosquitoes in Sri Lanka. These guidelines apply to: i. imported and indigenously developed GM mosquitoes that are intended for field trials or release in Sri Lanka,  and ii. all life forms including eggs, larvae, pupae, and adults as well as reproductive cells.