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Living Modified Organism
(LMO)
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Herbicide tolerant canola
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CLB-1
No
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Person:BASF Plant Science GmbHCarl-Bosch-Str. 38Ludwigshafen,
67056 , GermanyPhone: +49 621 60-0,Fax: +49 621 60-42525,Email: global.info@basf.com,
A canola (Brassica napus) event that is tolerant to the imidazolinone herbicides imazamox and imazapyr. Canola event CLB-1 was developed using site-directed mutagenesis of the AHAS3 gene in B. napus.
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The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
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BCH-ORGA-SCBD-12083-7 Organism Brassica napus (Turnip, Rapeseed, Canola Plant, Oilseed Rape, Rape, BRANA)Crops
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- Other (Site Directed Mutagenesis)
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
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BCH-GENE-SCBD-110261-1 Acetohydroxy acid synthase 3 gene Promoter | Brassica napus (Turnip, Rapeseed, Canola Plant, Oilseed Rape, Rape, BRANA)Promoter
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BCH-GENE-SCBD-110260-1 Acetohydroxy acid synthase 3 gene | Brassica napus (Turnip, Rapeseed, Canola Plant, Oilseed Rape, Rape, BRANA)Protein coding sequence | Resistance to herbicides (Imidazolinone, Sulfonylurea)
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BCH-GENE-SCBD-110262-1 Acetohydroxy acid synthase 3 gene terminator | Brassica napus (Turnip, Rapeseed, Canola Plant, Oilseed Rape, Rape, BRANA)Terminator
Canola event CLB-1 was developed through sequential site-directed mutagenesis of the AHAS3 gene in canola cells. Mutated cells were selected on the basis of tolerance to imazapyr and regenerated to produce plants. Canola event CLB-1 was identified as a successful mutant based on molecular analyses, herbicide efficacy and agronomic evaluations and was thus chosen for further development.
This gene encodes an acetohydroxyacid synthase (AHAS) enzyme, which is also referred to as an acetolactate synthase (ALS) enzyme. The herbicide tolerance trait in canola event CLB-1 is conferred by two point mutations, an alanine to threonine substitution at position 122 and a serine to asparagine substitution at position 653, in the AHAS3 gene.
These mutations result in a modified AHAS3 enzyme carrying two amino acid substitutions which render the enzyme insensitive to imidazolinone herbicides, including imazamox and imazapyr.
The canola event CLB-1 imidazolinone herbicide tolerance trait is under the control of the native AHAS3 promoter and is believed to be constitutively expressed.
EN
This gene encodes an acetohydroxyacid synthase (AHAS) enzyme, which is also referred to as an acetolactate synthase (ALS) enzyme. The herbicide tolerance trait in canola event CLB-1 is conferred by two point mutations, an alanine to threonine substitution at position 122 and a serine to asparagine substitution at position 653, in the AHAS3 gene.
These mutations result in a modified AHAS3 enzyme carrying two amino acid substitutions which render the enzyme insensitive to imidazolinone herbicides, including imazamox and imazapyr.
The canola event CLB-1 imidazolinone herbicide tolerance trait is under the control of the native AHAS3 promoter and is believed to be constitutively expressed.
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- Food
- Feed
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EN
- Decision Document DD2014-101 - CFIA [ English ]
