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Living Modified Organism
(LMO)
The image below identifies the LMO through its unique identifier, trade name and a link to this page of the BCH. Click on it to download a larger image on your computer. For help on how to use it go to the LMO quick-links page.
Lignin-modified maize (Maize CCR3)
EN
CCR3
No
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- Organization: VIB - Flanders Interuniversity Institute for Biotechnology () | BCH-CON-SCBD-42293-1Organization:VIB - Flanders Interuniversity Institute for Biotechnology ()Rijvisschestraat 120 9052 Zwijnaarde, Belgium Tel.: +09 244 66 11,
, BelgiumPhone:Fax: +09 244 66 10,Email: vib@vib.be,Website: www.vib.be,
The maize (Zea mays) was genome edited with CRISPR-Cas to introduce a mutation in the endogenous cinnamoyl-CoA reductase 3, which resulted in the inactivation of the gene. Due to the knockout, the maize cells have a reduced lignin composition in their cell wall. This is expected to improve digestibility and thus feed conversion rate for downstream uses and applications.
The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
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BCH-ORGA-SCBD-246-6 Organism Zea mays (Maize, Corn, MAIZE)Crops
EN
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Lignin-modified maize (Maize CCR1)| VIB - Flanders Interuniversity Institute for Biotechnology | Changes in quality and/or metabolite content (Lignin)
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Lignin-modified maize (Maize CCR2)| VIB - Flanders Interuniversity Institute for Biotechnology | Changes in quality and/or metabolite content (Lignin)
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Reference record not found (F1DDD91F-4E3C-3324-423F-A3C9204A082C)
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Reference record not found (DF90A16E-083A-94B2-16F0-7F68864FD982)
pHb-U9-ZmCas9-NOST-AG-EF1a-tDTomato
EN
- Gene editing (e.g. CRISPR-Cas, etc.)
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
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BCH-GENE-SCBD-277336-1 Cinnamoyl-CoA reductase 3 | Zea mays (Maize, Corn, MAIZE)Protein coding sequence | Changes in quality and/or metabolite content (Lignin)
The genome-edited maize was initially transformed to introduce the genome editing machinery (CRISPR-Cas), which then could induce a mutation in the cinnamoyl-CoA reductase 3 gene. The mutation resulted in a knock-out mutation and non-functional gene product. Subsequent breeding (backcrossing) was performed to remove the genetic elements originally introduced from the vector.
EN
- Feed
EN
EN
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Related LMO(s) | 2 | |
| Risk Assessment generated by a regulatory process | Living modified organism(s) | 1 | |
