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Risk Assessment generated by a regulatory process (RA)
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BCH-RA-BR-299507-1   |   PDF   |   Print   |  
last updated: 16 Jun 2026
General Information
Risk assessment of corn event MON 87429 - Technical Opinion 8035/2022
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05 May 2022
Risk assessment details
  • MON-87429-9 - Dicamba, glufosinate, quizalofop and 2,4-dicholorophenoxyacetic acid tolerant maize with tissue-specific glyphosate tolerance
    | Monsanto | Resistance to herbicides (Glufosinate, Glyphosate), Tolerance to 2,4-dichlorophenoxyacetic acid, Tolerance to 3,6-dichloro-2-methoxybenzoic acid (dicamba), Tolerance to quizalofop
MON 87429 corn was produced by the Agrobacterium-mediated transformation methodology using the plasmid PV-ZMHT519224. This plasmid contains a unique transfer DNA (T-DNA), which is delineated by right and left end regions. T-DNA contains the dmo expression cassettes, pat, ft_t and cp4 epsps. After transformation, traditional breeding, segregation, selection and sorting were used to identify plants that contained the dmo, pat, ft_t and cp4 epsps expression cassettes and did not contain any plasmid array sequences.
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Methodology and points to consider
Within the scope of Art. 14, CTNBio considered that the commercial release for planting genetically modified corn MON 87429 complies with the relevant norms and legislation that aim to guarantee the biosafety of the environment, agriculture, human and animal health.
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The evaluation of the agronomic and phenotypic characteristics of MON 87429 corn, using current cultivation and management practices, leads to the conclusion that the commercial release of MON 87429 corn is not expected to have an adverse effect on the agronomic practices used in the corn crop.
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It is not potentially causing significant environmental degradation or human health.
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Corn is a family crop that lacks any of the attributes commonly associated with weeds and has a long history of safe consumption. Therefore, the conventional control corn used in the transformation process was included in the studies to serve as an adequate basis of comparison for the MON 87429 corn. at a single locus within the maize genome and that both junctions originate from the same locus of the MON 87429 maize genome, linked by a known and expected contiguous DNA sequence. Extensive evaluation of the FT_T protein and previous evaluations of the DMO, PAT and CP4 EPSPS proteins expressed in MON 87429 maize confirm that these proteins are unlikely to be toxins or allergens. An extensive evaluation of the phenotypic and agronomic traits of MON 87429 maize and environmental interactions demonstrates that this genetically modified maize does not have an increased risk of weed traits when compared to conventional maize. An assessment of the potential impact for non-target organisms (NTOs), including organisms beneficial to agriculture, indicates that MON 87429 maize is not expected to have an adverse effect on other organisms when compared to conventional maize under normal agricultural practices. The evaluation of the agronomic and phenotypic characteristics of MON 87429 corn, using current cultivation and management practices, leads to the conclusion that the commercial release of MON 87429 corn is not expected to have an adverse effect on the agronomic practices used in the corn crop.
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Field experiments to assess phenotypic and agronomic characteristics, and environmental interactions of MON 87429 corn, compared to conventional control corn and commercial references, were conducted during the 2018/2019 harvest at six sites in Brazil (Vertuan, 2019b). The experimental stations where this study was conducted were: Luís Eduardo Magalhães, BA (BALM); Dourada Waterfall, MG (MGCH); Smile, MT (MTSO); Rolândia, PR (PRRO); Don't Touch Me, RS (RSNM); and Santa Cruz das Palmeiras, SP (SPSD). The identities of MON 87429 corn and conventional control corn were confirmed by PCR analysis and commercial references were identified through the manufacturer's label. Thus, the presence of pat, dmo, ft_t and cp4 epsps genes was duly certified in MON 87429 corn. The experimental design used was randomized blocks with four replications. MON 87429 corn (test), conventional control corn (control) and commercial references (references) were evaluated at each site. The results obtained from agronomic and phenotypic characteristics of MON 87429 maize were compared to the results obtained from conventional control maize per site and combined. Commercial hybrids (commercial references) represented the natural variability of the parameters evaluated in the studies. The collected data were submitted to statistical analysis (t test) to compare the averages of MON 87429 corn in relation to conventional control corn, at a significance level of 5%. The phenotypic observations and environmental interactions evaluated in this study demonstrate that MON 87429 maize does not differ consistently from conventional control maize, and that the significant differences found were occasional and do not represent characteristics that constitute potential environmental risks and potential increase in the persistence of the crop as a plant. weed. Based on this information, it can be concluded that MON 87429 corn is as safe as the conventional control corn used in the study for the parameters evaluated.
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MON87429 corn is not potentially causing significant environmental degradation or human health.
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CTNBio considered that the commercial release for planting genetically modified corn MON 87429 complies with the relevant rules and legislation that aim to guarantee the biosafety of the environment, agriculture, human and animal health.
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Molecular traddicional methods. 
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Information sharing with other databases
Yes
Yes
Yes
Yes
Yes
Additional information
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