Molecular profiling — a tool for addressing emerging gaps in the comparative risk assessment of GMOs | BCH-VLR-SCBD-103556 | Biosafety Virtual Library Resources | Biosafety Clearing-House

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last updated: 01 Jun 2012

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Molecular profiling — a tool for addressing emerging gaps in the comparative risk assessment of GMOs
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Heinemann, J.A.; Kurenbach, B.; Quist, D. School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
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Centre for Integrated Research in Biosafety (INBI)   BCH-ORG-SCBD-16293-5
  • Academic or research institute
School of Biological Sciences University of Canterbury Private Bag 4800
Christchurch,
8140, New Zealand
Phone: +64 3 364 2500,
Fax: +64 3 364 2590,
Environment International Elsevier http://www.journals.elsevier.com/environment-international/
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2011-10
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Environment International Volume 37, Issue 7, October 2011, Pages 1285–1293
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Copyright © 2011, Elsevier
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Abstract
Assessing the risks of genetically modified organisms (GMOs) is required by both international agreement
and domestic legislation. Many view the use of the “omics” tools for profiling classes of molecules as useful in
risk assessment, but no consensus has formed on the need or value of these techniques for assessing the risks
of all GMOs. In this and many other cases, experts support case-by-case use of molecular profiling techniques
for risk assessment.
We review the latest research on the applicability and usefulness of molecular profiling techniques for GMO
risk assessment. As more and more kinds of GMOs and traits are developed, broader use of molecular profiling
in a risk assessment may be required to supplement the comparative approach to risk assessment. The
literature-based discussions on the use of profiling appear to have settled on two findings: 1. profiling
techniques are reliable and relevant, at least no less so than other techniques used in risk assessment; and 2.
although not required routinely, regulators should be aware of when they are needed. The dismissal of routine
molecular profiling may be confusing to regulators who then lack guidance on when molecular profiling
might be worthwhile. Molecular profiling is an important way to increase confidence in risk assessments if the
profiles are properly designed to address relevant risks and are applied at the correct stage of the assessment.
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Additional Information
Identifier (ISBN, ISSN, etc.)
DOI:10.1016/j.envint.2011.05.006
Keywords and any other relevant information
Keywords: Genomics; Transcriptomics; Proteomics; Metabolomics; Epigenomics; Genetically modified organisms; Risk assessment
How to obtain the resource
http://www.sciencedirect.com/science/article/pii/S0160412011001322
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