The present legislative study on the mainstreaming of biosafety was commissioned by the Secretariat of the Convention on Biological Diversity.1 In the present study, the term “biosafety mainstreaming” refers to the integration of biosafety in domestic cross-sectoral and sectoral legislation, policies and institutional frameworks, taking into account national circumstances and priorities. Through in-depth analysis of international and national laws and policies and domestic examples of biosafety mainstreaming, the study provides a comprehensive overview of biosafety obligations and the practical ways in which biosafety measures can be mainstreamed into the national laws, policies and institutional frameworks of the Parties to the Cartagena Protocol on Biosafety to the Convention on Biological Diversity,2 the Nagoya- Kuala Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety3 and the Convention on Biological Diversity. This legislative study aims at assisting Parties in achieving the integrated implementation of the Cartagena Protocol. Its target audience may include both those engaged, at the national level, in the development and implementation of biosafety-related legislation, and those engaged in the development and implementation of cross-sectoral and sectoral policies and laws that are indirectly relevant to biosafety.