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Genetic element
(GENE)
last updated: 02 Dec 2025
Uroporphyrinogen-III (UPG) synthase
EN
-
CS-hem4-KOMPAEN
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Hydroxymethylbilane hydrolyaseEN
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URO3SEN
CS-hem4-PICPA
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-106439-4 Organism Komagataella pastoris (Yeast)Fungi
EN
Uroporphyrinogen III synthase
EN
Uroporphyrinogen III synthase (URO3S) is a cytosolic enzyme that catalyzes the ring closure of hydroxymethylbilane (HMB) and facilitates the "flipping" of the D ring to produce uroporphyrinogen III (URO'GEN III).
This enzyme catalyses the fourth step of the heme B cofactor biosynthesis. High intracellular concentration of this cofactor is important for active heme-containing globin proteins. Munro et al. (2009)
EN
EN
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
