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Living Modified Organism
(LMO)
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Vectormune® AI
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N/A
No
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Person:Dr Alexis Henry Gaetan GouxPresident of CIBio,Rua Manuel Joaquim Filho, 303 Pulínia - SPPaulínia, São Paulo
13140-000, BrazilPhone: 551938337700,Fax: 55193833-7722,Email: alexisgoux@ceva.com,Website: http://www.ceva.com.br/,Related OrganizationCeva Saúde Animal Ltda (CEVA)Private sector (business and industry)Rua Manuel Joaquim Filho, 303 Pulínia - SPPaulínia, São Paulo
13140-000, BrazilPhone: 551938337700,Fax: 55193833-7722,Email: alexisgoux@ceva.com,Website: http://www.ceva.com.br/,
The Vectormune® AI poultry vaccine is based on a Marek's Disease virus strain FC-126 (HVT FC-126), which is a non-pathogenic serotype of turkey herpesvirus (HVT), which is commonly used as a vaccine strain. The recombinant, modified virus expresses the H5 subtype of the hemagglutinin (HA) protein of the Avian Influenza virus (AIV). The vaccine is expected to confer protection to Avian influenza, which is a major respiratory disease in poultry.
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The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
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BCH-ORGA-SCBD-105225-3 Organism Meleagrid alphaherpesvirus 1 (Turkey herpesvirus, Meleagrid herpesvirus 1)Viruses
Turkey Herpesvirus (HVT) strain FC-126
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rHVT/AI
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- Direct DNA transfer (Homologus recombination)
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
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BCH-GENE-SCBD-45883-4 Hemagglutinin gene | Influenza A virus (Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu)Protein coding sequence | Production of medical or pharmaceutical compounds (human or animal) (Vaccines)
The biological agent, called rHVT / AI, contains a recombinant turkey herpesvirus (HVT), which expresses the hemagglutinin (HA) protein (H5 subtype) of the Avian Influenza virus (AIV). The HA gene is under control of the Cytomegalovirus promoter and was inserted into an intergenic non-coding region of the HVT genome.
The inserted donor DNA fragment was obtained through amplifying the HA gene (H5 subtype) from the single-stranded RNA genome of the AIV using polymerase reverse transcriptase (RT-PCR) chain reaction. The AIV HA gene is expected to be expressed in several recombinants. This gene is also used in a similar avian yaws-influenza vector vaccine, which is licensed by the USDA.
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The inserted donor DNA fragment was obtained through amplifying the HA gene (H5 subtype) from the single-stranded RNA genome of the AIV using polymerase reverse transcriptase (RT-PCR) chain reaction. The AIV HA gene is expected to be expressed in several recombinants. This gene is also used in a similar avian yaws-influenza vector vaccine, which is licensed by the USDA.
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- Vaccine
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- Efficacy of a Recombinant Turkey Herpesvirus AI (H5) Vaccine in Preventing Transmission of Heterologous Highly Pathogenic H5N8 Clade 2.3.4.4b Challenge Virus in Commercial Broilers and Layer Pullets.pdf [ English ]
- Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus.pdf [ English ]
