The genetic modification introduced in MON 15985 X MON 88913 cotton did not result in important differences in chemical composition relative to nutrients, being within the normal range of variation between conventional varieties. The possibility of the transgenic plant becoming a weed species, as well as the crossing of MON 15985 X MON 88913 cotton with other cotton plants to originate a weed is negligible. B.thuringiensis is a soil microorganism and the exposure of living organisms and the environment to this bacterium or any element extracted from it is an event that occurs abundantly in nature, not resulting in a significant risk to the soil microbiota. Genetically modified plants with the cry genes of B. thuringiensis and the cp4 epsps gene of Agrobacterium strain CP4 have been approved by regulatory agencies in several countries, including CTNBio, without reports of adverse effects on the environment and human and animal health. Field studies carried out in Brazil on insect populations present in MON 15985 X MON 88913 cotton fields showed that the abundance of non-target insects was not affected when compared to conventional cotton, which demonstrates the specificity of Cry proteins for the target pests. The history of use of this MON 15985 X MON 88913 cotton in the world indicates that this variety is as safe for the environment and for human and animal health as the conventional varieties of cotton that have been used.